This study explains Chuan-shan’s study of the nature of things in pursuit of knowledge. Du Sishu daquan shuo (Thorough Explanation for Reading the Four Books) is used as the basis of the topic; since Chuan-shan’s study of the four books has a great scope, I have limited the topic to Daxue (The Great Learning), and only on the study of the nature of things in pursuit of knowledge. The focus on the text Du Sishu daquan shuo also allows for easier focus. This paper summarizes Chuan-shan’s ideas on the study of the nature of things in pursuit of knowledge. Section 2 discusses the usage of Chuan-shan’s dialectical unanimity between two extremes in Daxue, where there is action in knowledge and knowledge in action. Thus, it is said that the study of the nature of things in pursuit of knowledge is not only knowledge but also contains action. The study of the nature of things in pursuit of knowledge is not split into two from sincerity of the will. Section 3 discusses the nature and pursuit; although study of the nature of things in pursuit of knowledge is a consistent idea, it involves two processes that cannot be confused as one. Study of the nature of things and pursuit of knowledge are neither distinct nor mixed. Section 4 explains Chuan-shan’s conception of the study of the nature of things; he does not seek to study everything in the world, and this could serve as a response to the doubts of Yang-ming. Section 5 explains Chuan-shan’s conception of the pursuit of knowledge, separating “wisdom” from “benevolence, righteousness, propriety, wisdom” from “knowledge” in “pursuit of knowledge.” Here, Chuan-shan makes this distinction based on Yi-chuan’s saying that “Buddhists are based on heart, the Confucian sages are based on Heaven.” This shows that at the time of the writing Chuan-shan supported the Confucianism of Cheng and Zhu and opposed that of Lu and Wang.